DOSING FOR PEDIATRIC PATIENTS UNDER 2 YEARS OF AGE

 
Date of Birth
Date of Birth

MG/Kg BASED DOSING CALCULATIONS

Initiate Sotalol IV treatment with 30 mg/m² three times per day (90 mg/m² total daily dose) in patients with normal renal function, subsequently titrating to a maximum of 60 mg/m² three times daily, if clinically indicated and the patient tolerates the higher doses. † Calculator uses BSA (Mosteller formula) and Age Factor.

  • Ensure frequent monitoring of the QTc interval and heart rate. Sotalol IV should be used with particular caution if the QTc is greater than 500 ms on therapy. Reduce the dose or discontinue treatment if QTc is greater than 550 ms.
  • Use of Sotalol IV in any age group with decreased renal function should be at lower doses or at increased intervals between doses.

For patients <2 years of age, Sotalol IV dose should be reduced by a factor that depends on age. 

Oral Sotalol is 90-100% bioavailable. The corresponding dose of intravenous Sotalol IV, therefore, slightly less than that of the oral dose.